منابع مشابه
Argatroban in thrombotic stroke.
Evidence for the potential use of direct thrombin inhibition in the treatment of acute stroke is reviewed. Reduction of secondary microthrombi and improved regional collateral cerebral blood flow is the proposed mechanism of action of thrombin inhibition for the treatment of cerebral ischemia. A clinical study in Japan found that argatroban administered within 48 h of stroke symptom onset is sa...
متن کاملSilent stroke in patients with acute thrombotic stroke
Introduction: Brain stroke is the most common neurologic disorder and also the most common cause of mortality and morbidity in neurtologic patients. Thanks to new methods of radiography such as MRI, brain vascular lesions including silent stroke are demonstrated more carefully. This study considers the frequency of silent stroke in patients with acute thrombotic stroke in Rafsanjan by using M...
متن کاملThrombotic cocktail in stroke.
A 35-year-old woman was admitted after a sudden left-arm deficit, which was preceded by 3 weeks of the same transient episodes lasting less than 5 minutes each. She was being treated for menorrhagia with tranexamic acid and was also using oral contraceptives. Three weeks before, she had a Mycoplasma pneumoniae respiratory infection. MRI showed a recent ischemia in the territories of the right m...
متن کاملThe Argatroban and Tissue-Type Plasminogen Activator Stroke Study
See related article, page 770. Developing new interventions for hyperacute stroke remains an important aim because current treatment options remain limited to alteplase, aspirin, hemicraniectomy, and stroke unit care. Over the last 20 years, drug developments have largely focused on fibrinolytic, neuroprotective, and anticoagulant strategies. Although the first is proven, the second and third r...
متن کاملEffects of argatroban therapy, demographic variables, and platelet count on thrombotic risks in heparin-induced thrombocytopenia.
STUDY OBJECTIVES We investigated the effects of the direct thrombin inhibitor argatroban, patient demographics, and the platelet count on thrombotic risks in heparin-induced thrombocytopenia (HIT), a serious thrombotic condition, to determine if argatroban provides effective antithrombotic therapy in patients with HIT without increasing bleeding. DESIGN We retrospectively analyzed thrombotic ...
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ژورنال
عنوان ژورنال: Pathophysiology of Haemostasis and Thrombosis
سال: 2002
ISSN: 1424-8840,1424-8832
DOI: 10.1159/000069108